Two cuboid-spored species of Entoloma (E. laccarioides and E. parvifructum) are described from S-China. Entoloma laccaroides is recognized by the umbilicate and whitish pileus, cuboid basidiospores, numerous conspicuous broadly fusoid to utriform pleurocystidia, cutis-like pileipellis with intracellular pigment, and presence of clamp connections. Entoloma parvifructum is characterized by the small, conico-convex and pale brown to brown pileus, comparatively large cuboid basidiospores, and cutis-like pileipellis with intracellular and encrusting pigment. The phylogenetic position and taxonomic relationships of E. laccaroides are compared and discussed with nrLSU sequences reported for various other cuboid-spored species kept in GenBank.