Lactarius desideratus Verbeken & Stubbe nov. sp. and L. uapacae Verbeken & Stubbe nov. sp. are described from primary rainforest in Cameroon. Both species are characterized by very small and yellowish basidiocarps, but their microscopical features are very different, placing one of them in L. section Plinthogali and one in L. sect. Chamaeleontini.