A synopsis of the current knowledge about the poroid Hymenochaetaceae from Southern Brazil (States Paraná, Santa Catarina and Rio Grande do Sul) is presented. Forty-two species belonging to nine genera are reported from the areas surveyed. An annotated, partly illustrated, checklist and identification keys are provided. The new combinations Fomitiporia bambusarum and Fulvifomes rhytiphloeus are also proposed.