A revision is presented of the genus Ehretia P. Browne sensu stricto for Madagascar and the Comores. Ehretia cymosa Thonn. and E. obtusifolia A. DC. are both known also from Africa, but the remaining species (E. australis J.S. Mill., E. decaryi J.S. Mill., E. meyersii J.S. Mill., E. phillipsonii J.S. Mill., and E. seyrigii J.S. Mill.) are all endemic and described as new.