During past years different studies have attempted to describe the tetrapod fauna of Iran, most of which have focused on the herpetofauna. However there is no coherent study of the endemic species of Tetrapoda in Iran. In this study, we provide a list of endemic species of Tetrapoda in Iran, mention their habitat, distribution, their conservation status (IUCN) and important biological note. Eighty endemic species of Tetrapoda occur in Iran, of which 82.50% are reptiles. Thirty-eight species (47.50% of total endemic species of Tetrapoda) have no submitted data to IUCN; of which 35 species are reptiles. Additional studies are needed to provide data about the conservation status of tetrapod fauna of Iran, especially the endemic fauna.